What lesion may be in association with desmoplastic melanoma?
Nerve infiltration or neurotropism is found in about half of desmoplastic melanomas. Lymphocytic nodular aggregates may be seen in association with desmoplastic melanoma, but are not diagnostic.
Is cytokeratin positive in melanoma?
The cytokeratin pattern of different tumour types, other than melanomas, is constant and assists in tumour progression from the very early stage up to late metastasis. All melanomas are vimentin-positive in all cells. Some melanomas are also reported to express cytokeratin.
What is a Naevoid melanoma?
English. Nevoid melanoma is a type of skin cancer. It begins when the melanocytes in the skin grow out of control and form tumors. Melanocytes are the cells responsible for making melanin, the pigment that determines the color of the skin.
What is a Sox 10 stain?
SOX-10 is a nuclear transcription factor involved in the differentiation of neural crest cells to melanocytes. 2. Its nuclear pattern differentiates itself from the other commonly used melanocytic markers. It has been shown to be both a sensitive and specific marker in staining melanomas.
What does desmoplastic melanoma look like?
The main sign of desmoplastic melanoma is a spot that may look like a scar in texture and appearance. It tends to develop on the face, scalp, neck, and sun-exposed areas of the arms and legs. The spot can be any color but is most often pink or red.
How serious is desmoplastic melanoma?
The five-year overall survival (OS) for DM ranges between 67-89%. Advancing age, male gender and head and neck location are associated with an increased risk of DM-specific death. Controversy persists regarding the prognosis of DM compared with non-desmoplastic melanomas.
Is melanoma CK7 positive?
A. Of the above, CK7 is the best screening marker for primary, extramammary Paget disease. Sox10 would be positive in a melanocytic lesion (i.e. melanoma in situ), p63 positive in squamous cell carcinomas or primary adnexal neoplasms and uroplakin is positive in pagetoid urothelial intraepithelial neoplasia (PUIN).
What is Nevoid?
Listen to pronunciation. (NEE-voyd BAY-sul sel KAR-sih-NOH-muh SIN-drome) A rare, inherited disorder that affects many organs and tissues in the body. People with this disorder have a very high risk of developing basal cell skin cancer during adolescence or early adulthood.
Is a desmoplastic melanoma malignant?
Desmoplastic malignant melanoma is a rare variant of spindle cell melanoma, commonly seen in older adults, on sun-exposed areas. It accounts for 1-4% of all cases of cutaneous melanoma. The common location of the desmoplastic melanoma is the head and neck region, whereas, other sites are less common.
What does positive CK7 mean?
For the CK7 negative group, no tumor cells yielded positive IHC staining results for CK7. For the CK7 positive group, diffuse or focal CK7 positive tumor cells were present in tumor tissue. The diffuse distribution of CK7 positive tumor cells was often present in poorly differentiated CRCs.
What does CK7 stain for?
CK7 will variably stain the majority of cells in biliary and gastric tumors. 3. Carcinomas that are almost invariably negative but may occasionally show rare CK7-positive cells include hepatomas, duodenal ampulla carcinomas, colon carcinomas, and adrenal cortical tumors.
What is vimentin stain?
Vimentin stains virtually all spindle cell neoplasms—mesenchymal spindle cell neoplasms and sarcomatoid carcinomas included. However, vimentin stains a subset of carcinomas regularly and to a significant degree, and this may be useful in the context of a panel of antibodies to narrow a differential diagnosis.
Which histologic findings are characteristic of desmoplastic melanoma?
Desmoplastic melanoma (DM) is histologically characterized by a proliferation of spindle melanocytes dispersed in a collagenous stroma that can be mistaken for a variety of neoplasms.
What is the role of vimentin staining in the diagnosis of mesenchymal tumors?
Vimentin staining confirms mesenchymal origin of some tumors; may be the only positive stain in certain cases and thus confirms that the tissue is capable of staining (Am J Surg Pathol 2011;35:1722) May confirm mesenchymal origin but there are numerous exceptions, so relatively nonspecific
Which immunostain panel is best for the diagnosis of spindle cell melanoma?
We conclude that a panel of S-100p, WT1, SOX10, p75 and nestin may constitute the optimal panel with the most sensitive and specific combination of immunostain available for the diagnosis of DM. Keywords: desmoplastic melanoma; immunohistochemistry; melanoma; spindle cell melanoma.
Is immunocytochemistry useful in the diagnosis of desmoplastic malignant melanoma?
Our findings indicate that immunocytochemistry is of less value in the diagnosis of desmoplastic malignant melanoma that it is with other types of malignant melanoma.