What is CD138 a marker for?
During normal B-cell development, cells acquire expression of CD138, also known as syndecan-1 (SDC1), a marker highly specific for terminally differentiated normal plasma cells (1). CD138 is a heparin sulphate proteoglycan that controls tumor cell survival, growth, adhesion and bone cell differentiation in MM (2).
What is plasma cell neoplasm?
Plasma cell neoplasms are diseases in which abnormal plasma cells or cells form tumors in the bones or soft tissues of the body. The plasma cells also make an antibody protein, called M protein, that is not needed by the body and does not help fight infection.
What does CD138 stain?
CD138 is expressed on plasma cells and can be useful in the diagnosis of plasma cell neoplasms. Epithelial cells and endothelial cells may also express CD138. In normal tonsil tissue, CD138 strongly stains the membranes of mature plasma cells and squamous epithelial cells.
What is a CD138 positive plasma cells?
CD138 is a classic plasma cell marker and can be found on both normal polyclonal or abnormal monoclonal plasma cells. Being CD138 positive and knowing the total plasma cell % from the core bone specimin would be the best markers to understand the extent of bone marrow infiltration.
What is the ICD 10 code for plasma cell neoplasm?
ICD-10-CM Code for Multiple myeloma and malignant plasma cell neoplasms C90.
What does CD38 negative mean?
In contrast, the CD38- negative group required minimal or no treatment, remained treatment-free for a longer time period and had prolonged survival (P < 0.05). CD38 expression was a robust marker in the majority of patients in that it was stable over time and not significantly influenced by chemotherapy.
What is CD138 endometritis?
The transmembrane heparin sulfate proteoglycan syndecan-1 (CD138) is a syndecan, which is a specific marker of plasma cells. Therefore, in current clinical practice, CD138 immunohistochemistry is used for the detection of chronic endometritis to improve its diagnosis rate [11].
Is plasma cell neoplasm reportable?
This neoplasm is not reportable.
Is plasma cell leukemia the same as multiple myeloma?
Plasma cell leukemia is a subtype of multiple myeloma. Inside the bones is a substance called marrow. Marrow is spongy and produces stem cells, blood, and some other substances. Multiple myeloma happens when plasma cells in the bone marrow grow out of control.
What does negative for neoplasm mean?
Negative: The margins don’t contain cancerous cells. Close: There are cancerous cells in the margin, but they don’t extend all the way to the edge. You may need more surgery.
Is a neoplasm always a tumor?
A neoplasm is an abnormal growth of tissue that can be benign (noncancerous) or malignant (cancerous). Benign tumors (noncancerous neoplasms) usually grow slowly and don’t spread.
What is CD138 biopsy?
Can CD138 be used to isolate CD138+ plasma cells from plasma cell myeloma?
Introduction: The use of CD138 to isolate CD138(+) plasma cells (PCs) from plasma cell myeloma (PCM) patients’ bone marrow samples has been used extensively in myeloma research.
What happens if CD138 test is negative?
If CD138 positive: Indicates Myeloma (plasma cell cancer) Or indicates Lymphoma (Lymphatic System Cancer) If CD138 negative: Usually indicates carcinomas (epithelial CE cancer) Directs towards other stains Procedure for CD138 Test
What is CD138 stain used for?
What is CD138 Test? CD138 is a protein present on plasma cells in the bone marrow, and on certain epithelial cells. The protein is useful to diagnose any neoplasms (tumors) growing in plasma cells. If a patient is to be tested for cancer, CD138 stains can be used to spot tumor cells.
What is the best way to diagnose cd138-pcm?
Recognizing the presence of CD138 − PCM combined with morphology and other plasma cell markers, such as CD38 and MUM1, will be helpful for a correct diagnosis.