Are there different types of multiple sclerosis?
There are three main types of MS – relapsing, primary progressive and secondary progressive. MS affects everyone differently. Even if you have the same type of MS as someone else, you probably won’t experience the same symptoms in the same way.
What is the pathogenesis of multiple sclerosis?
The pathogenesis of multiple sclerosis is characterised by a cascade of pathobiological events, ranging from focal lymphocytic infiltration and microglia activation to demyelination and axonal degeneration (figure 1). Multiple sclerosis.
What can trigger MS flare ups?
What Causes an MS Flare-Up?
- Stress.
- Fatigue.
- Heat.
- Infections.
- Diet.
- Medications.
- Smoking.
How does dimethyl fumarate work for MS?
Dimethyl fumarate is in a class of medications called Nrf2 activators. It works by decreasing inflammation and preventing nerve damage that may cause symptoms of multiple sclerosis.
What is the primary cause of multiple sclerosis?
The cause of multiple sclerosis is unknown. It’s considered an autoimmune disease in which the body’s immune system attacks its own tissues. In the case of MS , this immune system malfunction destroys the fatty substance that coats and protects nerve fibers in the brain and spinal cord (myelin).
Can you have mild MS all your life?
Multiple sclerosis (MS) is a condition that can affect the brain and spinal cord, causing a wide range of potential symptoms, including problems with vision, arm or leg movement, sensation or balance. It’s a lifelong condition that can sometimes cause serious disability, although it can occasionally be mild.
Can bg00012 slow down the progression of multiple sclerosis (MS)?
To determine if treatment with BG00012 can decrease the number of MS relapses during a certain time period. To determine if, over time, BG00012 treatment can decrease the number of certain types of brain lesions commonly seen in MS patients and slow down the time it takes for the disease to get worse.
What is the dosage for bg00012 240 mg?
In the first phase, participants will receive BG00012 240 mg (two 120 mg capsules) twice a day (BID) and 2 placebo capsules once a day. In the second phase participants will receive open-label BG00012 240 mg BID, for atleast 8 years.
What are the FDA approved treatments for primary progressive multiple sclerosis (MS)?
No agents are FDA approved for the primary progressive version of MS. FDA approved agents include four preparations of interferon β (Avonex, Rebif, Betaseron and Extavia), glatiramer acetate (Copaxone), mitoxantrone (Novantrone), natalizumab (Tysabri) and fingolimod (Gilenya). There are several drug undergoing phase II and III trials.
What do we know about the immunology of multiple sclerosis (MS)?
Many immunological studies have been done on the animal model for human MS known as the experimental autoimmune encephalomyelitis (EAE). Based on this model and observations of MS in humans, roles of several immunological pathways involved in MS are being explored.