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What was the first cholesterol drug?

What was the first cholesterol drug?

Triparanol(MER/29), which was introduced into clinical use in the U.S. in 1959, was the first cholesterol-lowering agent that inhibited cholesterol synthesis.

What is statins mechanism of action?

Mechanism of Action Statins work by competitively blocking the active site of the first and key rate-limiting enzyme in the mevalonate pathway, HMG-CoA reductase. Inhibition of this site prevents substrate access, thereby blocking the conversion of HMG-CoA to mevalonic acid.

What are the names of statin drugs?

They include:

  • Atorvastatin (Lipitor)
  • Fluvastatin (Lescol XL)
  • Lovastatin (Altoprev)
  • Pitavastatin (Livalo, Zypitamag)
  • Pravastatin (Pravachol)
  • Rosuvastatin (Crestor, Ezallor)
  • Simvastatin (Zocor)

Do statins have side effects?

While statins are highly effective and safe for most people, they have been linked to muscle pain, digestive problems and mental fuzziness in some people who take them and may rarely cause liver damage.

Which is the safest statin drug?

Simvastatin and pravastatin had the best safety profile, according to this review. Overall, the researchers found a 9 percent increased risk of type 2 diabetes in people taking statins.

What is the most popular statin drug?

Lipitor is the best-selling drug in the world, and the second-most potent statin medicine. Crestor is the newest and most potent statin.

Are plant sterols better than statins?

Statins are one of the most commonly prescribed drugs, in part because they’re well-tolerated by most people. And besides lowering cholesterol levels, they can help reduce the risk of heart attack or stroke. Plant sterols may not reduce the risk of heart attack or stroke like statins do.

What are the benefits of statins for cholesterol?

At the same time, they lower triglycerides and raise HDL cholesterol levels. Statins may also help to stabilize plaques in the arteries. That makes heart attacks less likely. Maintaining a healthy lifestyle while taking a statin can improve the effectiveness of the drug. Be sure to: Are There Side Effects of Statin Drugs?

What are the side effects of statins and sterols?

Statins can cause side effects for some people. These can include memory loss, muscle pain or damage, weakness, and nausea. Sterols, on the other hand, are not known to cause side effects when used short-term. Information on side effects from long-term use is not available. Plant sterols are not known to interact with other drugs.

What is an example of a statin?

Sometimes, a statin is combined with another heart medication. Examples are atorvastatin-amlodipine (Caduet) and ezetimibe-simvastatin (Vytorin). Should you be on a statin?