Table of Contents
What does high von Willebrand factor activity mean?
Increased concentrations of VWF antigen and VWF activity are not considered diagnostic. VWF is one of many acute phase reactants. This means that levels will be temporarily increased with infections, inflammation, trauma, and with physical and emotional stressors.
What is normal von Willebrand factor activity?
The normal range of VWF:Ag value varies with each laboratory, but is generally accepted to be between 50 and 200 IU/dL. Levels below 50 are considered to be low, although the degree to which these levels may be depressed on a population-wide basis generates controversy in the diagnosis of VWD.
Is PT elevated in von Willebrand disease?
The prothrombin time (PT) is normal in VWD. Although some laboratories may also include a skin bleeding time and platelet function analysis (PFA closure time) in their evaluation of an individual with suspected VWD, these tests lack sensitivity in persons with mild bleeding.
Why is aPTT increased in von Willebrand?
The aPTT is mildly prolonged in approximately 50% of patients with vWD. The prolongation is secondary to low levels of FVIII because one of the normal functions of vWF is to protect FVIII from degradation. The PT should be within reference ranges.
What does it mean when your clotting factor is too high?
Excessive clotting (thrombophilia) occurs when the blood clots too easily or excessively. Inherited and acquired disorders can increase blood clotting. Clots cause legs or arms to swell. Blood levels of proteins that control clotting are measured.
What causes elevated PTT levels?
An abnormal (too long) PTT result may also be due to: Bleeding disorders , a group of conditions in which there is a problem with the body’s blood clotting process. Disorder in which the proteins that control blood clotting become over active ( disseminated intravascular coagulation ) Liver disease.
Why would factor 8 be elevated?
Factor VIII levels can be elevated in a number of clinical conditions including carcinoma, leukemia, liver disease, renal disease, hemolytic anemia, diabetes mellitus, deep vein thrombosis, and myocardial infarction.
What does it mean if my Factor 8 is high?
If your levels of factor VIII are too high, you are likely at a higher risk for thrombosis, which is blood clot formation in your blood vessels. In this case, your doctor may perform additional tests or prescribe anticoagulant therapy.
What does a high von Willebrand factor mean?
What is high von Willebrand factor? Increased concentrations of VWF antigen and VWF activity are not considered diagnostic. VWF is one of many acute phase reactants. This means that levels will be temporarily increased with infections, inflammation, trauma, and with physical and emotional stressors. What is a low von Willebrand factor?
What is the normal range for von Willebrand factor?
– Related Questions What is the normal range for von Willebrand factor? In the general population, the mean level of plasma VWF is 100 IU per dL, with a normal reference range between 50 and 200 IU per dL.
Does von Willebrand disease affect blood clotting?
Von Willebrand disease is a lifelong bleeding disorder in which your blood doesn’t clot properly. People with the disease have low levels of von Willebrand factor, a protein that helps blood clot, or the protein doesn’t perform as it should.
What is the prevalence of von Willebrand disease (vWD)?
Von Willebrand disease (VWD) occurs with equal frequency among men and women, affecting up to 1% of the general population. 1,2 However, women are more likely to experience symptoms of VWD because of the increased bleeding it causes during their menstrual periods, during pregnancy, and after childbirth.