What cells are CD11b+?

Table of Contents

Integrin CD11b is primarily expressed on monocytes, macrophages, neutrophils, dendritic cells (DCs), NK cells, and a subset of B and T cells (23–28).

What is CD11b a marker for?

. CD11b (Mac-1): a marker for CD8+ cytotoxic T cell activation and memory in virus infection.

Do dendritic cells express CD11b?

The CD8+ dendritic cell subset CD8+ cDCs express no or low levels of the integrin CD11b and other macrophage markers (Table 1).

What are CD11c+ cells?

CD11c+ cells in the islets include macrophages, dendritic cells, and monocytes that serve multiple roles during the progression of T1D (4, 7–10).

Is CD11b a macrophage marker?

The CD11 protein is actually a heterodimer complex that consists of CD11b and CD18. CD11 is involved in numerous adhesion-related associations between cells such as monocytes, macrophages, natural killer (NK) cells, and granulocytes.

Are CD11b expressed T cells?

Abstract. We have found that CD11b, a cell surface integrin of macrophages, granulocytes, and NK cells, is expressed by a subset of CD8+ T cells that include both the active virus-specific CTL and the virus-specific memory CTL populations.

What is CD16 a marker for?

CD16 is often used as an additional marker to reliably identify different subsets of human immune cells. Several other CD molecules, such as CD11b and CD33, are traditionally used as markers for human myeloid-derived suppressor cells (MDSCs).

Is CD11b a myeloid marker?

CD11b is considered a pan-myeloid marker (expressed after granulocyte-monocyte progenitors (GMP) phase in the bone marrow). CD11c is a prefered marker for dendritic cells. But there is exceptions given the variety of tissue distribution of myeloid cells.

What is the difference between CD11b and CD11c?

Do B cells express CD11b?

Conclusion: Memory B cells express CD11b and, in contrast with naive B cells, have high migratory ability. CD11b plays an essential role in the homing process of memory cells.

What is CD14 and CD16?

Human monocytes are divided in three major populations; classical (CD14+CD16−), non-classical (CD14dimCD16+), and intermediate (CD14+CD16+). Each of these subsets is distinguished from each other by the expression of distinct surface markers and by their functions in homeostasis and disease.

What immune cells express CD16?

CD16 is involved in antibody-dependent cell-mediated cytotoxicity and is expressed on large granular lymphocytes (LGLs) of both NK- and T-cell types. Approximately 15–20% of the peripheral blood lymphocytes and a much smaller fraction (5%) of bone marrow lymphocytes express dim CD16.

What are B cell activation markers?

For most mature B cells the key markers include IgM and CD19, a protein receptor for antigens (Kaminski DA. Front Immunol. 2012). Activated B cells express CD30, a regulator of apoptosis. Plasma B cells lose CD19 expression, but gain CD78, which is used to quantify these cells.

What are CD14 cells?

CD14 is a glycolipid-anchored membrane glycoprotein expressed on cells of the myelomonocyte lineage including monocytes, macrophages, and some granulocytes. CD14 is a key molecule in the activation of innate immune cells and exists as a membrane-anchored or soluble form.

What is the CD marker for B cells?

Clusters of Differentiation (CD) proteins are a group of cell surface markers that can be used to identify different stages of B cell development or activation, including progenitor B cells, pre-pro-B cells, pro-B cells, pre-B cells, immature B cells, transitional B cells, marginal zone B cells, follicular B cells.

Do all B cells have CD20?

CD20 is expressed on all stages of B cell development except the first and last; it is present from late pro-B cells through memory cells, but not on either early pro-B cells or plasma blasts and plasma cells.

What is CD14 marker for?

Purpose: CD14, one of the main differentiation markers on the surface of myeloid lineage cells, acts as a key role in activation of LPS-induced monocytes. LPS (lipopolysaccharide) binds to LPS-binding protein in plasma and are delivered to the cell surface receptor CD14.

What is CD38 marker?

The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism, as well as some genetically determined conditions.

What is CD20 a marker for?

A protein found on B cells (a type of white blood cell). It may be found in higher than normal amounts in patients with certain types of B-cell lymphomas and leukemias. Measuring the amount of CD20 on blood cells may help to diagnose cancer or plan cancer treatment. CD20 is a type of tumor marker.

What does CD mean in CD20?

CD20 (cluster of differentiate 20) is a protein that is expressed on the surface of B cells, starting at the pre-B cell stage and on mature B cells in the bone marrow and in the periphery. CD20 is not expressed on hematopoietic stem cells, pro-B cells, or normal plasma cells.

What is CD11c and CD11b?

What is a circular CD11c + DC?

Circulating CD11c + DCs are typically CD11c high and major histocompatibility complex (MHC) class IIhigh but lineage-negative (Lin –), i.e., lacking markers for other cell lineages, such as T cells, monocytes, B cells, NK cells, granulocytes, and erythroid cells.

What does CD11 do in adhesion?

CD11 is involved in numerous adhesion-related associations between cells such as monocytes, macrophages, natural killer (NK) cells, and granulocytes. CD11 also regulates the uptake of complement-coated particles within cells.

Is CD11b a pan-macrophage marker?

In general, CD11b is considered a pan-macrophage marker, although this distinction is not earned. It is expressed on a huge variety of leukocytes and can be upregulated on activated cells irrespective of their naive expression status.