What is anti CD4 antibody?

What is anti CD4 antibody?

Anti-CD4. CD4 is a TCR coreceptor expressed on helper T cells and at lower levels on some APCs. Nondepleting CD4 antibodies have been used in small and large animal models of transplantation for tolerance induction.

What is anti CD8?

CD8 is found on a T cell subset of normal cytotoxic / suppressor cells which make up approximately 20 to 35% of human peripheral blood lymphocytes. The CD8 antigen is also detected on natural killer cells, 80% of thymocytes, on a subpopulation of 30% of peripheral blood null cells and 15 to 30% of bone marrow cells.

What is CD4 cell count?

What is a CD4 count? A CD4 count is a test that measures the number of CD4 cells in your blood. CD4 cells, also known as T cells, are white blood cells that fight infection and play an important role in your immune system.

How does antibody depletion work?

These antibodies are classically thought to work through a variety of mechanisms. It includes the inhibition of ligand binding to specific receptors, the blockade of receptor activation, thus interfering with signaling pathways, and/or through their ability to deplete tumor cells.

What is the CD4 count in a healthy person?

A normal CD4 count is from 500 to 1,400 cells per cubic millimeter of blood. CD4 counts go down over time if you do not take ART.

Do B cells cause autoimmune disease?

Through these mechanisms B cells are involved both in autoimmune diseases that are traditionally viewed as antibody mediated and also in autoimmune diseases that are commonly classified as T cell mediated.

What drugs deplete B cells?

Direct killing by monoclonal antibodies against B-cell surface molecules CD19, CD20 (rituximab, ocrelizumab), and CD22 (epratuzumab). The most widely tested category of anti-B-cell agents is anti-CD20 antibodies, which induce a broad and deep B-cell depletion.

What diseases are caused by B cells?

B-cell mediated disease

• Cancer. Many different B-cell malignancies have been described, such as non-Hodgkin’s lymphoma (NHL) and Hodgkin’s lymphoma (HL).
• Autoimmunity.
• Non-autoimmune inflammatory disease.
• Transplantation.
• Spread of human immunodeficiency virus (HIV)
• B-cell depletion therapy.

What is the CD4 antigen?

View more The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells.

What is the function of CD4 in T cells?

CD4 binds to MHC class II on the surface of antigen presenting cells and plays an important role both in T cell development and in optimal functioning of mature T cells. In T cells, CD4 associates with protein tyrosine kinase p56lck through its cytoplasmic tail.

How does the ze5 cell analyzer detect human CD4?

Data acquired on the ZE5 Cell Analyzer. Mouse anti human CD4 antibody, clone RPA-T4 recognizes human CD4, a ~55 kDa cell surface glycoprotein, primarily expressed on a subpopulation of T lymphocytes, on peripheral blood monocytes and on tissue macrophages.

What is rpa-t4 antibody?

Mouse anti human CD4 antibody, clone RPA-T4 recognizes human CD4, a 55 kDa cell surface glycoprotein that is primarily expressed on a subpopulation of T lymphocytes, on peripheral blood monocytes and on tissue macrophages.