What is the melting point of Acetanilide?
237.7°F (114.3°C)Acetanilide / Melting point
What is the formula of Acetanilide?
C8H9NOAcetanilide / Formula
What is the PH of acetanilide?
|Melting point||113-115 °C(lit.)|
|color||Off-white to beige to grayish-blue|
|PH||5-7 (10g/l, H2O, 25℃)|
What is the mechanism of acetanilide?
Acetanilide is prepared from aniline when it reacts with acetic anhydride/glacial acetic acid in the presence of zinc dust. A mixture of aniline, glacial acetic acid, acetic anhydride and zinc dust is refluxed under anhydrous condition and then poured the mixture into ice cold water to get acetic anhydride precipitate.
Is acetanilide acidic or basic?
Although aniline is a base, the substitution of a hydrogen atom by the COCH3 group leads to a remarkable decrease in basicity, with the result that acetanilide is considered to be a weak base (pKb = 12.9–13.4) (Beillstein 2002; Giffney and O’Connor 1975; Ahumov 1974).
What is the function of acetanilide?
acetanilide, synthetic organic compound introduced in therapy in 1886 as a fever-reducing drug. Its effectiveness in relieving pain was discovered soon thereafter, and it was used as an alternative to aspirin for many years in treating such common complaints as headache, menstrual cramps, and rheumatism.
Is acetanilide activating or deactivating?
Acetanilide, having a decent EWG, is a moderately-activated ring.
Why is acetanilide para directing?
Due to the presence of nitrogen atoms, the amide groups are ortho para directing. The acetamido group i.e., −NHCOCH3 present in acetanilide is a large group which effectively blocks the ortho position of the aromatic ring and thus only formation of para products is observed.
What is the PKA of acetanilide?
pK (28°): 13.0.
Is acetanilide a para director?
Is acetanilide an ortho para? The acetamido group (-NHCOCH3 ) is an ortho-para directing group in electrophilic aromatic substitution reactions. In the bromination of acetanilide, only para-substitution is observed.
What is acetanilide (acetanilid)?
Under the name acetanilid it formerly figured in the formula of a number of patent medicines and over the counter drugs. In 1948, Julius Axelrod and Bernard Brodie discovered that acetanilide is much more toxic in these applications than other drugs, causing methemoglobinemia and ultimately doing damage to the liver and kidneys.
What is the Koc of acetanilide?
A Koc of 27 was experimentally determined for acetanilide, using silt loam and sandy loam, with % organic matter ranging from 1.09-5.92 (Kom was converted to Koc by multiplying by 1.724), and pH ranging from 5.9-7.5(4).
What is the difference between acetanilide and acetylarylamine?
Acetanilide is a white to gray solid. (NTP, 1992) N-Acetylarylamine is an odourless solid chemical of leaf or flake-like appearance. It is also known as acetanilide, N-phenylacetamide, acetanil, or acetanilid, and was formerly known by the trade name Antifebrin.
What is the difference between acetanilide and N-phenylacetamide?
ACETANILIDE is a white to gray solid. N-phenylacetamide is a member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen is substituted by a phenyl group. It has a role as an analgesic. It is a member of acetamides and an anilide. It derives from an acetic acid.