Table of Contents
Does acetylsalicylic acid dissolve in HCl?
The published solubility data of aspirin, although not always consistent, suggest a solubility of more than 4 mg/mL at 37o C in 0.1 N HCl (Al-Maaieh and Aburub 2005).
Is acetylsalicylic acid the same as salicylic acid?
Salicylic acid is an organic compound with the formula HOC6H4CO2H. A colorless, bitter-tasting solid, it is a precursor to and a metabolite of aspirin (acetylsalicylic acid).
How do you Hydrolyse aspirin?
Measure out 100 cm3 of the pH 7.5 buffer solution into a conical flask. Put this on a magnetic stirrer/electric hotplate and bring the temperature up to 70 °C. 2. Add 0.10 g of powdered aspirin to the buffer solution and stir the mixture gently until the aspirin is completely dissolved.
Why is HCl added to salicylic acid?
Methyl red is commonly used for such a titration. The aqueous solution of sodium salicylate (water soluble as it is salt) is titrated with standard HCl, When HCl is added, salicylic acid is precipitate. At the equivalence point only NaCl is present and the first drop of acid will produce color change of the indicator.
What is acetylsalicylic acid used to treat?
Aspirin (acetylsalicylic acid) is a pharmaceutical drug used to reduce pain1,2 or inflammation. 3 It is classified as a non-steroidal anti-inflammatory drug (NSAID). Aspirin can be used to treat: mild to moderate pain.
What does acetylsalicylic acid do to your body?
In addition to chemically blocking your body’s pain signals, aspirin can also reduce the risk of heart attacks and certain strokes. Aspirin works to prevent the platelets in your blood from clumping and clotting in your arteries, thereby reducing these risks by improving blood flow to your heart and brain.
What happens when aspirin is hydrolyzed?
The Hydrolysis of Aspirin. Aspirin (2-ethanoyloxybenzoic acid or acetylsalicylic acid) hydrolyses to produce 2-hydroxybenzoic acid and ethanoic acid. When administered, aspirin hydrolyses in the body. If aspirin tablets are stored in a humid environment, such as a bathroom, they hydrolyze.
What happens when you put aspirin in vinegar?
If you have an old bottle of aspirin tablets you may find they have a slight smell of vinegar, especially if they have become damp. As you have seen, when aspirin reacts with water the carboxylic acid that it forms, by hydrolysis of the ester group, is acetic acid.
Does salicylic acid react with HCl?
The aqueous solution of sodium salicylate (water soluble as it is salt) is titrated with standard HCl, When HCl is added, salicylic acid is precipitate. At the equivalence point only NaCl is present and the first drop of acid will produce color change of the indicator.
What happens when HCl is added to methyl salicylate?
Upon acidification with HCl the carboxylic acid product precipitates out of solution. The ester methyl salicylate is the active odor component of “oil of wintergreen” and its distinctive smell is readily apparent. Many esters of carboxylic acids have fragrant odors.
What is the structure of acetylsalicylic acid?
Structure of Aspirin (acetylsalicylic acid) 1 carboxylic acid functional group (R-COOH) 2 ester functional group (R-O-CO-R’) 3 aromatic group (benzene ring)
What happens if a cat eats acetylsalicylic acid?
Daily doses of acetylsalicylic acid in cats produced toxic hepatitis, vomiting, weight loss, and poor appetite in the low-dose group (33–63 mg kg−1 day −1) and anemia, gastric lesions, and death in the high-dose group (81–130 mg kg −1 day −1 ). High doses of aspirin given to mice on day 6 of gestation produced large incidence of lethal deformities.
How is aspirin prepared from salicylic acid and acetic acid?
Aspirin can be prepared by reacting salicylic acid and acetic anhydride in the presence of an acid catalyst. Structure of Aspirin (acetylsalicylic acid) Aspirin (acetylsalicylic acid) contains three groups: carboxylic acid functional group (R-COOH)
What is acetylsalicylic acid used for?
Acetylsalicylic acid or ASA (Fig. 1.9), another pharmaceutical product having antiinflammatory, antipyretic, and analgesic properties, is broadly used in the treatment of fever, headache stemming from cold, renal function and is also effective in Alzheimers disease [255,256], cancer, and cardiovascular illness [258,259].